Wells' syndrome.

Eosinophilic cellulitis (Well’s syndrome)= باهتلا جيسن يولخ تاضمحلاب Eosinophilic cellulitis (Wells syndrome) In 1971, George Wells first described this syndrome as a recurrent granulomatous dermatitis with eosinophilia.1 Wells and Smith renamed it eosinophilic cellulitis in 1979.2

Eosinophilic cellulitis (Wells’ syndrome) caused by a temporary henna tattoo

Eosinophilic cellulitis (Wells' syndrome) is an uncommon condition of unknown etiology. Wells' syndrome is usually seen in adulthood but very rare in childhood. Although pathogenesis of the disease is not very clear, it is a hypersensitivity reaction developing against a variety of exogenous and endogenous antigenic stimuli. Paraphenylenediamine is a strong allergen frequently used as a tempora...

Eosinophilic Cellulitis: Report of a case and literature review

Eosinophilic cellulitis is a rare skin disorder may be idiopathic or be associated with other conditions. We present a 42- year- old female patient with bilateral atypical cellulitis – like lesions on her arms. The patient had a documented infection with Leptospira recently, and had a positive history for fascioliasis two years before.Histopathology examination of the l...

Muckle–Wells syndrome: clinical perspectives

Muckle-Wells syndrome (MWS) is a rare autoinflammatory disorder. It is due to NLRP3 gene mutations, responsible for excessive caspase-1 activation and interleukin 1β processing. MWS is the intermediate phenotype of severity of cryopyrin-associated periodic syndrome. Urticarial rash, conjunctivitis, recurrent fever, arthralgia, and fatigue are the main clinical manifestations of MWS. Yet, sensor...

Successful renal transplantation in Muckle–Wells syndrome treated with anti-IL-1β-monoclonal antibody

We report the first case of a 32-year-old woman with Muckle-Wells syndrome and biopsy-proven systemic AA amyloidosis and end-stage renal disease. She was treated with canakinumab 150 mg subcutaneously every 8 weeks and underwent renal transplantation. Fourteen months after renal transplanation, the patient had no flares of Muckle-Wells syndrome and no evidence of amyloidosis in the renal transp...

Wells syndrome in adults and children: a report of 19 cases.

BACKGROUND Wells syndrome, an uncommon inflammatory dermatosis, is characterized by protean cutaneous manifestations, suggestive but not specific histopathologic findings, and usually a recurrent course. Because of its original description as a distinct entity, it has come to be regarded as an abnormal eosinophilic response to a number of causative agents. OBSERVATIONS The medical records of ...